[Retracted] Styrylchromones: Biological Activities and Structure-Activity Relationship

Table 11

Summary of the 3-SC which antitumoral activity was studied in works using tumor and normal cell lines and description of the observed effects in each type of cells used. The table displays the antitumoral activity shown for the studied 3-SC according to the criterion: selectivity index greater or equal to 2.

3-SC	Studied cell lines		Observed effect(s)	Ref.
	Tumoral	Non-tumoral
2	Ca9-22, HSC-2, HSC-3 and HSC-4 cells	HGF, HPLF and HPC cells	Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells	[78]
34				[43]
36 - 39
41			High cytotoxicity against HGF, HPLF and HPC cells	[78]
42 - 47			Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells	[43]
49, 50
165				[78]
167			High cytotoxicity against HGF, HPLF and HPC cells
168			Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells; induction of apoptosis and mitotic arrest in HSC-2 cells
169			Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells; and high cytotoxicity against HGF, HPLF and HPC cells
170 - 174			Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells
175			Decreased cell viability of Ca9-22, HSC-2, HSC-3 and HSC-4 cells; induction of apoptosis and mitotic arrest in HSC-2 cells

Ca9-22: human oral squamous cell carcinoma Ca9-22; HGEP: primary gingival epithelial cell; HOK: human oral keratinocyte; HPC: human pulp cell; HGF: human gingival fibroblast; HPLF: human periodontal ligament fibroblast; HSC-2: human squamous cell carcinoma-2; HSC-3: human squamous cell carcinoma-3; HSC-4: human squamous cell carcinoma-4.