[Retracted] Styrylchromones: Biological Activities and Structure-Activity Relationship

Table 13

2-SC studied for the neuroprotective activity, their chemical structures, and summary of the observed neuroprotective effects.

Chemical structure	2-SC	Observed effect(s)	Ref.
	1	Inhibition of MAO-A and MAO-B activities, displaying MAO-B selectivity	[80]
	5	NA	[8]
	6	Neuroprotective activity against glutamate-induced neurotoxicity in P12 pheochromocytoma cells	[9]
	11	Inhibition of AChE, BChE and BACE1	[11]
	30	Inhibition of MAO-A and MAO-B activities	[80]
	56	Inhibition of MAO-A and MAO-B activities, displaying MAO-B selectivity
	58
	88
	92
	104 - 111
	112, 113	Inhibition of MAO-B activity, displaying MAO-B selectivity
	114	Inhibition of MAO-A and MAO-B activities, displaying MAO-B selectivity
	115	Inhibition of MAO-B activity, displaying MAO-B selectivity

NA: no activity was found under tested experimental conditions. AChE: acetylcholinesterase; BACE1: β-site amyloid precursor protein cleaving enzyme 1; BChE: butyrylcholinesterase; MAO: monoamine oxidase.