ELK1 Promotes Epithelial-Mesenchymal Transition and the Progression of Lung Adenocarcinoma by Upregulating B7-H3

Figure 5

ELK1 promoted tumor growth of LUAD in vivo. (a) A549 cells (sh-NC vs. sh-ELK1) were injected subcutaneously in nude mice and representative bioluminescence image of LUAD mouse models for the detection of tumor growth at different time nodes. Knockdown of ELK1 significantly inhibited tumor growth in nude mice. (b) After five weeks, the tumors in the nude mice were removed and weighed. Knockdown of ELK1 significantly inhibited tumor weight in nude mice. (c) H&E staining and IHC evaluated the expression changes of Ki67 or PNCA after ELK1 knockdown (scale bar, 50 μm). (d) H460 cells (vector vs. ELK1) were injected subcutaneously in nude mice and representative bioluminescence image of LUAD mouse models for the detection of tumor growth at different time nodes. Overexpression of ELK1 promoted tumor growth in nude mice. (e) After five weeks, the tumors in the nude mice were removed and weighed. Overexpression of ELK1 promoted tumor weight in nude mice. (f) H&E staining and IHC evaluated the expression changes of Ki67 or PNCA after ELK1 overexpression (scale bar, 50 μm). .

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