CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration

Figure 1

Elevated expression of CGRP and its receptor in degenerated human IVD tissue. (a, b) The protein expression of CGRP and its receptors, CALCRL and RAMP 1, was increased with the progression of IVDD. (c) Higher mRNA expression of CALCRL and RAMP1 was observed in IL-1β- (10 ng/mL) treated NP cells. (d) The protein amount of CGRP receptors, CALCRL and RAMP1, in human nucleus pulposus inn vitro was gradually elevated with the increasing concentration of IL-1β. ^/#, ^/##, ^/###, and ^/####; ns: no significance.  μm.

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