CD4+CD25+ Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke
Table 2
Univariate comparison of patients with hemorrhagic versus nonhemorrhagic transformation.
Hemorrhagic transformation ()
Nonhemorrhagic transformation ()
Characteristic
Age on admission (y), median (range)
70 (53-91)
71 (60-87)
0.357
Women, (%)
14 (43.8%)
30 (50.8%)
0.514
NIHSS on admission, median (range)
14 (6-23)
15 (3-22)
0.558
Interventional parameters
TICI (2b-3 score), (%)
27 (84.4%)
57 (96.6%)
0.092
Bridging therapy, (%)
20 (62.5%)
32 (54.2%)
0.656
TOAST, (%)
0.538
Atherosclerotic
12 (37.5%)
18 (30.5%)
Cardioembolic
18 (56.3%)
38 (64.4%)
Other
1 (6.2%)
3 (5.1%)
Vascular risk factors, (%)
Hypertension
18 (56.3%)
45 (76.3%)
0.059
Diabetes mellitus
4 (12.5%)
14 (23.7%)
0.272
Coronary heart disease
6 (18.8%)
12 (20.3%)
0.557
Clinical outcome, (%)
0.514
mRS (0-2)
17 (53.1%)
35 (59.3%)
mRS (3–6)
15 (46.9%)
24 (40.7%)
Mortality
8 (25%)
7 (11.9%)
0.141
Thrombus components, median (SD)
CD4+ cells
2 (1.7)
13 (5.6)
<0.001
CD25+ cells
3 (1.5)
11 (7.2)
<0.001
NIHSS: National Institutes of Health Stroke Scale; TICI: thrombolysis in cerebral infarction; TOAST: Trial of Org 10172 in Acute Stroke Treatment; mRS: modified Rankin Scale. Primary target variables.