Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases

Figure 2

The interference mechanisms of NO in fibrotic diseases. NO can reduce the amount of ROS by peroxynitrite formation and which subsequently attenuates the activation of the NF-κB signaling pathway to inhibit the expression of fibrosis and inflammatory-related genes. Moreover, NO can also downregulate the expression of TGF-β to attenuate its downstream signaling pathway.