Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction

Figure 7

Angiotensin II promoted the activation of NLRP3 inflammasome in human NP cells in vitro. (a) Immunofluorescence results for the expression of NLRP3 in human NP cells induced by Ang II, . . (b) Ang II promoted the secretion of inflammation-related cytokines in human NP cells (). (c) The effects of Ang II on the expression of NLRP3 inflammasome-related proteins and inflammatory mediators in human NP cells (). (d) The results of western blot were quantified as graphs (). , , , .

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