Oxidative Medicine and Cellular Longevity / 2021 / Article / Fig 8

Research Article

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction

Figure 8

Systematic activation of RAS promoted the local expression of ACE in SHR nucleus pulposus tissue in vivo.(a, b) The blood pressure was measured with a noninvasive Tail-Cuff System Western (ALC-NIBP, Shanghai Alcott Biotech) at 3 M, 6 M, and 12 M, respectively, according to previous study [34]. (c) Western blot results for the expression of ACE and AT1 in the rat NP tissue at the age of 6 and 12 months, respectively (). (d) The results of western blot were quantified (). (e) Immunofluorescence results for the expression of AGT in the rat NP tissue at the age of 12 months (). (f) The results of immunofluorescence were quantified (). SBP: systolic blood pressure; DBP: diastolic blood pressure. , , , .

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