The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease
Table. 3
Correlations between neurofilament light chain, certain WAIS subtests, and the specific brain regions of the PD patients.
Correlation () of the specific brain regions
Putamen, L
Hippocampal complex, R
Putamen, R
Superior temporal gyrus, R
Cingulate gyrus, R
Middle temporal gyrus, R
(-32, -12, -11)
(14, -7, -26)
(27, 12, 3)
(57, -12, 16)
(12, -25, 43)
(50, 12, -38)
Misfolding protein
Neurofilament light chain
-0.297
0.052
-0.096
-0.462
-0.224
0.071
WAIS subtests
Picture completion
0.176
0.149
0.300
0.581
0.312
0.085
Vocabulary
0.402
0.517
0.363
0.382
0.433
0.340
Digit symbol-coding
0.298
0.137
0.123
0.421
0.199
0.129
Similarities
0.305
0.418
0.358
0.338
0.454
0.357
Block design
0.353
0.253
0.179
0.315
0.383
0.173
Arithmetics
0.452
0.429
0.273
0.367
0.308
0.325
Matrix reasoning
0.484
0.440
0.423
0.429
0.394
0.389
Digit span
0.621
0.376
0.466
0.615
0.420
0.431
Comprehension
0.279
0.402
0.358
0.316
0.300
0.370
Letter-number sequencing
0.525
0.523
0.615
0.329
0.586
0.660
Correlations between among neurofilament light chain and the specific brain regions of the PD patients were performed by partial correlation after controlling for age, and gender. Correlations between certain WAIS subtests and the specific brain regions of the PD patients were performed by partial correlation after controlling for age, gender, and education. , uncorrected. with a Bonferroni corrected, accounting for multiple regions of interest and neuropsychiatric subtests comparisons.
