Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis

<div><i>Pon2</i> mRNA expression level in WT mice changes upon aging. LT-HSCs, ST-HSCs, MPPs, CMPs, GMPs, MEPs, and liver cells were obtained from young (2-3 months) and aged (&gt;9 months) WT mice. <i>Pon</i>2, <i>Gapdh</i>, and <i>Actb</i> mRNA expression was analyzed by qRT-PCR. <i>Pon</i>2 mRNA expression was normalized to <i>Gapdh</i> and <i>Actb</i> mRNA expression. The relative <i>Pon</i>2 mRNA expression in LT-HSCs from young WT mice was set to 1. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis 