The Expression and Function of Circadian Rhythm Genes in Hepatocellular Carcinoma

Table 2

The genetic alteration of circadian rhythm genes in hepatocellular carcinoma.

Circadian genes	SNP	Function of SNP	References
NPAS2	rs1053096	Associated with OS in transcatheter arterial chemoembolization-treated HCC patients	[26]
	rs2305160	Associated with OS in transcatheter arterial chemoembolization-treated HCC patients
	rs9223
	rs1562313
	rs2305158
	rs3811558
CRY1	rs3809236	Associated with OS and RFS of HCC patients	[31, 32]
	rs1056560
CRY2	rs6798		[31, 32]
	rs2292910
PER1	rs3027178	Associated with OS and RFS of HCC patients	[31, 32]
	rs2585405
PER2	rs934945		[31, 32]
	rs2304669
PER3	rs228669	Associated with OS of HCC patients	[31, 32]
	rs2640908	Associated with OS of HCC patients
	rs228729	Associated with RFS of HCC patients
	rs172933
	rs2859390

HCC: hepatocellular carcinoma; OS: overall survival; RFS: recurrence-free survival.