Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals

Figure 2

Network pharmacology analysis of the SHM formula. (a) Distribution of active phytochemicals in SHM herbs against OA. (b) The shared targets between SHM potential targets and OA targets. (c) Network of herb-active phytochemical target for SHM against OA. (d) Network of 63 key targets based on central network evaluation. The size of nodes is proportional to the degree centrality by topology analysis. (e) The top ten pathways identified by KEGG enrichment analysis and the corresponding key targets. SHM: shenjinhuoxue mixture; OA: osteoarthritis; KEGG: Kyoto Encyclopedia of Genes and Genomes Pathway database.

(a)

(b)

(c)

(d)

(e)