Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation
Serine deficiency exacerbated hepatic lipid accumulation. Cpt1a: carnitine palmitoyltransferase 1a; Acadm: medium-chain acyl-CoA dehydrogenase; DGAT: diacylglycerol O-acyltransferase. Relative mRNA expression of Cpt1a (a), Acadm (b), DGAT1 (c), and DGAT2 (d). (e) Oil Red O staining (×200). Arrows, lipid droplet. CONT: mice were fed on the control diet; NS: mice were fed on the serine- and glycine-deficient diet; NCT: mice were fed on the control diet and supplemented with NCT-503. Data are presented as ..a,bMeans of the bars with different letters were significantly different among groups ().
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