LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer

Figure 1

Upregulation of the LINC00467 expression in BRCA based on the integration of gene chips and RNA sequencing. (a) Flow chart: after the five gene chips of GEO were, respectively, analyzed with GEO2R, differentially expressed lncRNAs were screened out based on annotations of the Ensemble and RefSeq database, and then the RRA of the package was used to screen the significantly different molecules in multiple datasets. (b) The top 10 differentially expressed lncRNAs based on RRA analysis (five upregulated and five downregulated) were calculated in the heat maps. (c) Another dataset of GEO was used to verify the differential expression of LINC00467 (samples of tissues). (d) Gene chips of GEO were used to verify differential expression of LINC00467 (samples of cell lines). (e) LINC00467 expression in breast cells (extreme low positive rate). (f) LINC00467 expression in BRCA (extreme high positive rate). (g) LINC00467 expression in BRCA CTCs. (h) Correlation between LINC00467 and phenotypes of BRCA CTCs based on the analysis of GSE75367. .

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