LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer

Figure 7

Genome amplification and expression levels of LINC00467 were associated with T cell infiltration. (a) CD8+ T cells showed lower infiltration in samples with LINC00467 amplified based on the TIMER2.0 database. (b) CD4+ T cells showed lower infiltration in samples with LINC00467 amplified based on the TIMER2.0 database. (c) The LINC00467 expression was significantly negatively correlated with ESTIMATE Score/Immune Score/Stromal Score based on the TIMER2.0 database. (d) The LINC00467 expression in the TCGA BRCA cohort was negatively correlated with a variety of immune cells based on the ImmLnc database. (e) GSEA enrichment analysis based on the ImmLnc database showed that the LINC00467 expression in TCGA BRCA cohort had the highest negative correlation with the TCR signal pathway.

(a)

(b)

(c)

(d)

(e)