Ginsenoside Rg5 Inhibits Human Osteosarcoma Cell Proliferation and Induces Cell Apoptosis through PI3K/Akt/mTORC1-Related LC3 Autophagy Pathway

Figure 7

Schematic outline of ginsenoside Rg5 inhibits the human osteosarcoma cell through LC3 autophagy-related apoptosis. Under physiological conditions, the activation of PI3K/AKT/mTORC1 could inhibit the LC3 activity and caspase-3-related cell apoptosis. But Rg5 activated LC3 activity through inhibiting the phosphorylation of PI3K/AKT/mTORC1 to inhibit the human osteosarcoma cell proliferation and induce cell apoptosis.