DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis
Neuroprotective effect of DCA on HBMEC cells. (a) CCK8 assay was used to detect the viability of cells after injury. (b, c) The productions of SOD and MAD were measured to assess oxidative damage. (d) DCA inhibits PDK2, a key metabolic protein of mitochondrial TCA cycle, and activates the expression of PDH. (e) DCA activated the protein expressions of Nrf2 and HO-1. and . The comparison between cohorts is marked in the figure.
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