Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function

Figure 3

Effects of KB on glucose and FA metabolism in Tregs. Effects of KB on extracellular acidification rates (a) and oxygen consumption (b, c) in CD4⁺CD25⁺Foxp3⁺ cells derived from the spleen. Effects of KB on intracellular FA contents (d) and absorption (e) in CD4⁺CD25⁺Foxp3⁺ cells. Effects of KB on key genes involved in FA synthesis and oxidation (f). Effects of KB on CD25⁺Foxp3⁺ cells derived from CD4+ T cells (g). values were derived either from the ANOVA followed by SNK for multiple comparisons (a–c, f, g) or the -test (d, e). Basic Resp: basic respiration; Max Resp: maximum respiration; ATP Prod: ATP production.

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