Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function

<div>Effects of KB on IL-33/ST2L signaling and its role in KB-induced MAMs and Treg alterations. Flow cytometry detected the changes of membrane ST2L expression in CD4+CD25+Foxp3+ Tregs (a). Cultured medium levels of IL-33 and sST2 PBS-/KB-treated Tregs (b, c). Cultured medium levels of IL-33 and sST2 and MAMs in membrane-ST2L-negative/positive Tregs (d, e). Reinforcement of membrane-ST2L expression on Treg MAMs and Treg proportions in CD4+ T cells (f, g, h). sST2: soluble ST2; ST2L-: ST2L- Tregs; ST2L+: ST2L+ Tregs; Con: control vector; ST2L: ST2L vector. Levels of IL-33 were detected by ELISA after NP-40 treatment.</div>

Oxidative Medicine and Cellular Longevity

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Figure 5

Figure 5: Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function 

Figure 5 | Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function 