Bacteriocins: Potential for Human Health

Table 3

Anti-inflammation and immunomodulation effects of bacteriocins.

Bacteriocins	Classification	Resource	Highlights
Nisin A	Lanthipeptide	L. lactis	Decreasing the levels of IL-6, IL-8, and TNF-α and reduce the growth of bacteria in the wound [73]
Nisin Z	Lanthipeptide	L. lactis	Inhibiting S. agalactiae and S. aureus, alleviating mastitis in cows [74]
Nisin	Lanthipeptide	L. lactis	Increasing the level of IL-12 in macrophages [82], adjust the levels of inflammatory factors in both directions and promote immune balance [83]. Decrease the levels of TNF-α, TNF-β, NF-κB, IL-1, and ROS in mice [153]
Nisin P	Lanthipeptide	S. lactis SMN003	Regulating cytokine concentration to reduce uterine inflammation in rats [75]
Thiostrepton	Thiopeptide	Streptomyces sp.	Inhibiting psoriasis-like inflammation induced by TLR7, TLR8, and TLR9 [86]
Microcin M	Microcin	E. coli MC4100	Inhibiting intestinal pathogenic bacteria and reducing intestinal inflammation [77]
Microcin J25	Lasso peptide	E. coli	Improving intestinal inflammation of broiler and mouse caused by Salmonella and ETEC [78, 79]
Sublancin	Glycocin	B. subtilis 800	Enhancing macrophage function, increase CD 4^+ and CD 8^+ cells, thereby enhancing immune response [84, 85]. Inhibiting NF-κB, relieving intestinal inflammation [157]
Gassericin A	Circular bacteriocins	L. gasseri LA39	Binding to KRT19 thus promote fluid absorption and decrease secretion early-weaned piglets [158]
Salivaricin LHM	Class II	L. salivarius	Inhibiting inflammation caused by P. aeruginosa, with immune regulation in mice [81]
Plantaricin EF	Class IIb	L. plantarum	Reducing obesity and fat inflammation [76]
Lmo2776	Class IId	L. monocytogenes	Targeting the commensal P. copri and modulate intestinal infection in mice [159]