Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis

Figure 5

BSYS inhibited the polarization of microglia to M1 phenotype in EAE mice. (a, d) Immunofluorescence of SVZ and LE from mice in each group using antibodies against Iba1 (green) and iNOS (red). Scale bars: 100 μm. (b, e) Quantification of the percentage of iNOS+/Iba1+ cells in SVZ and LE. (c, f) Quantification of Iba + cells density in SVZ and LE. (g) Representative western blot images of iNOS in brain and spinal cord tissues. (h, i) Quantitative data for iNOS expression in brain and spinal cord tissues. Data are presented as ; compared with the NC group, ^##; compared with the EAE group, , .

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