Mitochondrial Dysfunction Contributes to Aging-Related Atrial Fibrillation

Table 5

The correlation of LTL with other clinical characteristics.

	Simple linear regression		Multiple linear regression
	Clinical parameters
Age (years)	-0.151	0.037	-0.111	0.110
BMI (kg/m^2)	-0.079	0.274
Smoking, (%)	0.119	0.099
History of CHD, (%)	-0.013	0.861
Hypertension, (%)	-0.046	0.529
Diabetes mellitus, (%)	0.115	0.114
Hyperlipidemia	0.128	0.077
Antihypertensive medication, (%)	-0.045	0.532
Glucose lowering treatment, (%)	0.103	0.155
Lipid-lowering medication, (%)	-0.025	0.726
SBP (mmHg)	0.068	0.352
DBP (mmHg)	-0.071	0.331
Laboratory parameters
TC (mmol/L)	0.015	0.836
TG (mmol/L)	-0.046	0.523
LDL-C (mmol/L)	0.041	0.571
HDL-C (mmol/L)	0.097	0.180
Cr (mmol/L)	0.020	0.785
BUN (mmol/L)	0.040	0.577
UA (mmol/L)	-0.138	0.057
FBG (mmol/L)	0.071	0.329
GHb (%)	0.047	0.519
CRP (mg/dL)	-0.200	0.005	-0.167	0.017
Echocardiographic parameters
LVEF (%)	0.021	0.771
LAD (mm)	-0.196	0.006	-0.165	0.018
Telomere-associated molecules
Leukocyte p53 mRNA	0.059	0.417
Leukocyte PGC-1α mRNA	0.168	0.020	0.131	0.160
Serum PGC-1α (pg/mL)	0.176	0.014	0.109	0.122

Abbreviations: BMI: body mass index; CHD: coronary heart disease; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Cr: creatinine; BUN: blood urea nitrogen; UA: uric acid; FBG: fasting blood glucose; GHb: glycated hemoglobin; CRP: C-reactive protein; LVEF: left ventricular ejection fraction; LAD: left atrial diameter; PGC-1α: peroxisome proliferator-activated receptor γ coactivator-1α. with italic font means statistically significant.