Research Article

Serum Interleukin-37 Increases in Patients after Ischemic Stroke and Is Associated with Stroke Recurrence

Table 2

Multivariate analysis of predictors of stroke recurrence.

PredictorsOR95% CI

3.322.03-6.13<0.001
NIHSS (per unit increase)1.161.05-1.300.008
Stroke etiology (cardioembolic vs. other)3.762.33-6.120.015
Atrial fibrillation (yes vs. no)2.451.83-3.030.002
Acute treatment, TPA-T (yes vs. no)0.320.25-0.40<0.001
IL-6 (per unit increase)1.211.11-1.300.003
CRP (per unit increase)1.431.20-1.580.009

The following variables were adjusted: age, sex, BMI, stroke etiology, vascular risk factors, prestroke and acute treatment, NIHSS score, and serum levels of IL-6, IL-37, CRP, and FSG. The reference used for the analyses was the lowest three quartiles (Q1-Q3), corresponding to an (Q4 vs. Q1-Q3). OR: odds ratio; CI: confidence interval; BMI: body mass index; NIHSS: National Institutes of Health Stroke Scale; TPA-T: tissue plasminogen activator-treated; CRP: C-reactive protein; IL-37; interleukin-37; IL-6: interleukin-6; FSG: fasting serum glucose.