Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity

<div>Hydrogen peroxide induced oxidative stress and inhibited cell proliferation. (a) Hydrogen peroxide increased malonaldehyde (MDA) concentrations in medium depending on the dosage of H<sub>2</sub>O<sub>2</sub>. (b) Hydrogen peroxide increased MDA concentrations in medium with time. (c) Hydrogen peroxide inhibited the balance of intracellular glutathione/glutathione disulfide (GSH/GSSG) depending on the dosage of H<sub>2</sub>O<sub>2</sub>. T-GSH: total glutathione. (d) Hydrogen peroxide inhibited the balance of intracellular GSH/GSSG with time. T-GSH: total glutathione. (e) Hydrogen peroxide dosage-dependently inhibited cell viability. (f) Hydrogen peroxide dosage-dependently inhibited cell proliferation, PCNA: proliferating cell nuclear antigen. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity 