Exploring the Role and Mechanism of pAMPKα-Mediated Dysregulation of Brf1 and RNA Pol III Genes

Figure 10

Schematic illustration of pAMPKα mediates dysregulation of Brf1 and Pol III gene transcription. In the study, high levels of Brf1 expression and pAMPKα are detected in human samples of lung cancer. Mechanism analysis indicates that the carcinogen MNNG induces pAMPKα to enhance Brf1 promoter activity, resulting in Brf1 expression and Pol III gene transcription, which increase the rates of cell proliferation and colony formation, eventually resulting in cancer development.