Exploring the Role and Mechanism of pAMPKα-Mediated Dysregulation of Brf1 and RNA Pol III Genes

Figure 2

High Brf1 expression correlated with a poor prognosis of lung cancer. (a) The IHC staining scores of Brf1 expression. 185 cases in paired different clinical stages of lung cancer tumor tissues show high Brf1 expression, compared to low expression of Brf1 expression corresponding to normal tissues of these cases (). (b) 226 cases of human lung cancer patients were performed for Kaplan-Meier analysis of the overall survival period. Lung cancer patients () with low versus high expression of Brf1 (Kaplan-Meier analysis with the log-rank test, ). (c) Histological classification of the 226 cases of lung cancer. (d) ROC curve analysis. The result reveals that patients with high Brf1 expression display short survival times.

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