Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Figure 7

Bacterial cooccurrence network pre- and posttreatment in the THD group. (a) Cooccurrence network of genera before treatment in the THD group. The network contained a big cluster, dominant by Clostridium-Ruminococcus-Parabacteroides cooccurrence cluster, and a small cluster centered on Pyramidobacter. Most of the SCFA-producing bacteria were contained in the two clusters. Bacteroides, an LPS-producing bacterium, competed with one genus and was complementary with two genera. (b) Cooccurrence network of genera after treatment in THD group. The cooccurrence network became more complicated after treatment, with more connections and higher complexity. While the Clostridium-Ruminococcus-Parabacteroides dominant cluster shrank caused by the significant increment of Ruminococcus, the Pyramidobacter dominant cluster enlarged and linked more SCFA-producing bacteria, especially two acetate-producing genera, Blautia and Acetobacterium. Bacteroides lost all correlations with other genera after treatment. Red line: negative correlation; blue line: positive correlation; colors of nodes stand for the phylum of the bacteria; sizes of the bubbles stand for the average abundance; the ellipses with different lines represent different clusters.

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