THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma
THAP9-AS1 promoted cell growth and invasion in vitro via the SOCS3/JAK2/STAT3 signaling pathway. (a) The protein expression of p-STAT3 was measured. (b) THAP9-AS1 promoted cell proliferation, which could be reversed by either SOCS3 or AG490. (c) Cell apoptosis was inhibited by THAP9-S1 but promoted by either SOCS3 or AG490. (d, e) The number of migrated and invaded cells was increased in the THAP9-AS1 groups and decreased in the SOCS3-expressing and AG490-treated groups; scale bars: 50 μm. (f) THAP9-AS1 promoted EMT progression by decreasing E-cadherin and increasing N-cadherin. ;;. AG490: inhibitor of JAK2/STAT3 signaling.
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