Oxidative Medicine and Cellular Longevity / 2021 / Article / Fig 6

Research Article

THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma

Figure 6

Dysregulation of THAP9-AS1/SOCS3 causes mitochondrial dysfunction. (a) ROS were reduced in the THAP-AS1 groups and restored in the SOCS3 and AG490 treatment groups; scale bars: 100 μm. (b) JC-1 staining was used to observe the mitochondrial membrane potential. The red fluorescence of the JC-1 probe indicates normal mitochondria, and the green fluorescence of the JC-1 probe indicates damaged mitochondrial potential; scale bars: 100 μm. ; .

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