Research Article
The Role of RIPC in Preventing Organ Damage, Inflammation, and Oxidative Stress during Lower Limb DSA: A Randomised Controlled Trial
Table 2
Mean change of organ damage biomarkers in the groups of the per-protocol population with respect to stenting.
| | RIPC | SHAM | value+ | value | Stent | value | Stent | No | Yes | No | Yes | Mean | Mean | Mean | Mean |
| Δhs-TropT (ng/L) | 0.51 | -0.09 | -0.15 | 0.48 | -0.31 | -0.54 | 0.56 | ΔCK-MBm (μg/L) | 0.65 | -0.45 | -0.08 | 0.26 | -0.36 | -0.56 | 0.33 | ΔNT-proBNP (pg/mL) | 0.66 | -54.0 | -39.6 | 0.34 | -51.0 | -23.0 | 0.87 | Δhs-CRP (mg/L) | 0.036 | 0.97 | 7.56 | <0.0001 | -0.93 | 2.57 | 0.059 | ΔGlucose (mmol/L) | 0.76 | 0.25 | 0.38 | 0.88 | -0.09 | 0.31 | 0.62 | ΔCreatinin (μmol/L) | 0.46 | 1.46 | 3.95 | 0.47 | 3.33 | 1.37 | 0.80 | ΔUrea (mmol/L) | 0.59 | 0.07 | 0.31 | 0.039 | 0.35 | -0.07 | 0.76 | ΔCystatin-C (mg/L) | 0.20 | 0.01 | 0.03 | 0.49 | 0.00 | -0.02 | 0.19 | ΔBeta-2 microglobuline (μg/L) | 0.20 | 14.2 | 142.3 | 0.69 | -13.8 | -3.7 | 0.10 | ΔeGFR (mL/min/1.73m2) | 0.47 | -0.8 | -3.1 | 0.37 | -2.9 | -1.2 | 0.95 | ΔAdiponectin (ng/mL) | 1 | 268 | -221.2 | 0.44 | 204 | 46 | 0.72 | ΔIL-18 (pg/mL) | 0.24 | 0.7 | 11.6 | 0.88 | 7.5 | 5.0 | 1 | ΔMPO (ng/mL) | 0.53 | 23.3 | 39.9 | 0.075 | 0.5 | 27 | 0.087 | ΔNGAL (ng/mL) | 0.90 | 9.9 | 11.6 | 0.38 | 5.4 | 5.1 | 0.089 | Δox-LDL (U/L) | 0.89 | -1.8 | -0.4 | 0.47 | -1.0 | 0.8 | 0.67 | ΔKIM-1 (pg/mL) | 0.56 | 1569 | 1741 | 0.44 | 881 | 645 | 0.17 | ΔL-FABP (ng/mL) | 0.72 | -0.06 | -0.04 | 0.084 | 0.11 | -0.14 | 0.81 | ΔIsoprostanes/creatinine (ng/mmol) | 0.026 | -7.8 | 3.5 | 0.005 | -11.6 | 2.1 | |
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Δ: mean change; +: adjusted to stenting; hs-TropT: high-sensitivity troponin T; CK-MBm: creatine kinase MB mass; NT-proBNP: N-terminal proBNP; Glc: glucose; MPO: myeloperoxidase; eGFR: estimated glomerular filtration rate; NGAL: neutrophil gelatinase-associated lipocalin; oxLDL: oxidized low-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; KIM-1: kidney injury molecule 1; L-FABP: liver-type fatty acid-binding protein.
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