PER2 Regulates Reactive Oxygen Species Production in the Circadian Susceptibility to Ischemia/Reperfusion Injury in the Heart
PER2 in circadian I/R susceptibility of the heart. Per2 mRNA (a) and (b) protein expression in mouse heart during a 24 h day. Quantification was normalized to GAPDH. ZT2 was set to 1 ( per time point, and vs. ZT2; one-way ANOVA with Bonferroni correction). (c) PER2 and potential target levels were determined by immunoblots with or without I/R injury at ZT2 and ZT14. Quantification of PER2, CPT1, and PDHB was normalized to GAPDH (–5, and vs. sham-ZT2; ## and ### vs. sham-ZT14; & and && vs. I/R-ZT2, two-tailed Student’s -test). Alpha was set as 0.05. Data are presented as the . The Holm-Sidak method was used to correct for multiple -tests.
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