Genomic and Transcriptome Analysis to Identify the Role of the mTOR Pathway in Kidney Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 1

(a–c) Heat map showing that mTOR scores were associated with other signaling pathways in KIRC. (a) The correlation with potentially targetable classical genes. (b) The correlation with sirtuin family genes. (c) The correlation with HDAC family genes. (d) Heat map showing the correlation between mTOR pathway genes and substances related to immune filtering. Purple means positive and yellow means negative. and . (e) Plot showing the degree of correlation; the area of the sphere represents the abs(correlation), and the color indicates the value. (f–j) Scatter diagram showing the specific relationship between the five immune-infiltration-related substances and the mTOR scores. It can be seen from the diagram that they are all negatively correlated. (k) The plot shows the correlation analysis between PD-1, CTLA-4, and the mTOR scores. In the figure, a scatter plot and color block are, respectively, used to represent their specific correlation and correlation coefficients. (l) Submap analysis indicating that the mTOR-inactive cluster could be more sensitive to PD-1 (the programmed cell death protein 1) inhibitors (nominal value = 0.029).

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