Research Article

The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

Table 2

Nrf2, SOD2, GPX1, and GSTP1 genotypes in relation to the risk of ccRCC.

GenotypesccRCC patients, (%)Controls, (%)OR (95% CI)a

Nrf2 (rs6721961)
 C/Cc166 (77)241 (72)1.00b
 C/A and A/Ad50 (23)95 (28)0.692 (0.370-1.295)0.250
SOD2 (rs4880)
 Ala/Alae45 (30)111 (21)1.00b
 Ala/Val and Val/Valf175 (70)225 (79)4.521 (2.167-9.432)<0.001
GPX1 (rs1050450)
 Pro/Prog109 (49)142 (42)1.00b
 Pro/Leu and Leu/Leuh113 (51)194 (58)0.567 (0.323-0.994)0.048
GSTP1 (rs1695)
 Ile/Ilei55 (25)159 (47)1.00b
 Ile/Val+Val/Valj168 (75)177 (53)3.714 (1.952-7.069)<0.001
GSTP1 (rs1138272)
 Ala/Alak197 (89)297 (89)1.00b
 Ala/Val+Val/Vall25 (11)39 (11)0.712 (0.309-1.642)0.426
GSTP1 (rs1695 and rs1138272)
 (Ile/Ile) (Ala/Ala)m54 (24)144 (43)1.00b
 (Ile/Ile) (Ala/Val+Val/Val)n1 (1)15 (4)0.000 (NAq)0.999
 (Ile/Val+Val/Val) (Ala/Ala)o143 (64)153 (46)3.250 (1.668-6.331)0.001
 (Ile/Val+Val/Val) (Ala/Val+Val/Val)p24 (11)24 (7)2.719 (0.970-7.624)0.057

aOR: odds ratio adjusted for age, gender, BMI, pack-years, and hypertension; CI: confidence interval; breference group; cC/C: carriers of both referent alleles; dC/A and A/A: carriers of at least one variant allele; eAla/Ala: carriers of both referent alleles; fAla/Val and Val/Val: carriers of at least one variant allele; gPro/Pro: carriers of both referent alleles; hPro/Leu and Leu/Leu: carriers of at least one variant allele; iIle/Ile: carriers of both referent alleles; jIle/Val and Val/Val: carriers of at least one variant allele; kAla/Ala: carriers of both referent alleles; lAla/Val and Val/Val: carriers of at least one variant allele; m(Ile/Ile) (Ala/Ala): carriers of both referent alleles for rs1695 and rs1138272; n(Ile/Ile) (Ala/Val+Val/Val): carriers of both referent alleles for rs1695 and at least one variant allele rs1138272; o(Ile/Val+Val/Val) (Ala/Ala): carriers of at least one variant allele for rs1695 and both referent alleles for rs1138272; p(Ile/Val+Val/Val) (Ala/Val+Val/Val): carriers of at least one variant allele for both rs1695 and rs1138272; qNA: not applicable.