The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

Table 3

Combined effect of Nrf2, SOD2, GPX1, and GSTP1 genotypes in relation to the risk of ccRCC carriers of at least one variant allele.

Genotypes	Nrf2 (rs6721961)		SOD2 (rs4880)		GSTP1 (rs1695)		GSTP1 (rs1138272)
	C/C^c	C/A and A/A^d	Ala/Ala^e	Ala/Val and Val/Val^f	Ile/Ile^i	Ile/Val+Val/Val^j	Ala/Ala^k	Ala/Val+Val/Val^l
Nrf2 (rs6721961) C/C^c
OR (95% CI)^a	—	—	—	—	1.00^b	3.211 (1.513-6.814)	1.00^b	1.067 (0.41-2.779)
	—	—	—	—	—	0.002	—	0.894
Nrf2 (rs6721961) C/A and A/A^d
OR (95% CI)^a	—	—	—	—	0.385 (0.095-1.564)	2.731 (1.107-6.739)	0.835 (0.430-1.621)	0.162 (0.019-1.408)
	—	—	—	—	0.182	0.029	0.594	0.099
SOD2 (rs4880) Ala/Ala^e
OR (95% CI)^a	1.00^b	0.308 (0.059-1.599)	—	—	1.00^b	4.796 (0.927-24.81)	1.00^b	0.594 (0.064-5.504)
	—	0.161	—	—	—	0.062	—	0.646
SOD2 (rs4880) Ala/Val and Val/Val^f
OR (95% CI)^a	3.234 (1.436-7.280)	2.918 (1.131-7.532)	—	—	5.875 (1.190-29.00)	19.724 (4.267-91.16)	4.374 (2.012-9.508)	3.290 (1.054-10.26)
	0.005	0.027	—	—	0.030	<0.001	<0.001	0.040
GPX1 (rs1050450) Pro/Pro^g
OR (95% CI)^a	1.00^b	0.423 (0.158-1.133)	1.00^b	3.653 (1.148-11.63)	1.00^b	5.476 (2.127-14.10)	1.00^b	0.826 (0.238-2.868)
	—	0.087	—	0.028	—	<0.001	—	0.763
GPX1 (rs1050450) Pro/Leu and Leu/Leu^h
OR (95% CI)^a	0.440 (0.223-0.868)	0.456 (0.188-1.057)	0.553 (0.144-2.120)	2.533 (0.793-8.094)	0.720 (0.239-2.165)	2.194 (0.912-5.287)	0.585 (0.322-1.063)	0.372 (0.115-1.199)
	0.018	0.067	0.388	0.117	0.558	0.079	0.079	0.098

^aOR: odds ratio adjusted for age, gender, BMI, pack-years, and hypertension; CI: confidence interval; ^breference group; ^cC/C: carriers of both referent alleles; ^dC/A and A/A: carriers of both referent alleles; ^eAla/Ala: carriers of both referent alleles; ^fAla/Val and Val/Val: carriers of at least one variant allele; ^gPro/Pro: carriers of both referent alleles; ^hPro/Leu and Leu/Leu: carriers of at least one variant allele; ⁱIle/Ile: carriers of both referent alleles; ^jIle/Val and Val/Val: carriers of at least one variant allele; ^kAla/Ala: carriers of both referent alleles; ^lAla/Val and Val/Val: carriers of at least one variant allele.