The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma
Table 3
Combined effect of Nrf2, SOD2, GPX1, and GSTP1 genotypes in relation to the risk of ccRCC carriers of at least one variant allele.
Genotypes
Nrf2 (rs6721961)
SOD2 (rs4880)
GSTP1 (rs1695)
GSTP1 (rs1138272)
C/Cc
C/A and A/Ad
Ala/Alae
Ala/Val and Val/Valf
Ile/Ilei
Ile/Val+Val/Valj
Ala/Alak
Ala/Val+Val/Vall
Nrf2 (rs6721961) C/Cc
OR (95% CI)a
—
—
—
—
1.00b
3.211 (1.513-6.814)
1.00b
1.067 (0.41-2.779)
—
—
—
—
—
0.002
—
0.894
Nrf2 (rs6721961) C/A and A/Ad
OR (95% CI)a
—
—
—
—
0.385 (0.095-1.564)
2.731 (1.107-6.739)
0.835 (0.430-1.621)
0.162 (0.019-1.408)
—
—
—
—
0.182
0.029
0.594
0.099
SOD2 (rs4880) Ala/Alae
OR (95% CI)a
1.00b
0.308 (0.059-1.599)
—
—
1.00b
4.796 (0.927-24.81)
1.00b
0.594 (0.064-5.504)
—
0.161
—
—
—
0.062
—
0.646
SOD2 (rs4880) Ala/Val and Val/Valf
OR (95% CI)a
3.234 (1.436-7.280)
2.918 (1.131-7.532)
—
—
5.875 (1.190-29.00)
19.724 (4.267-91.16)
4.374 (2.012-9.508)
3.290 (1.054-10.26)
0.005
0.027
—
—
0.030
<0.001
<0.001
0.040
GPX1 (rs1050450) Pro/Prog
OR (95% CI)a
1.00b
0.423 (0.158-1.133)
1.00b
3.653 (1.148-11.63)
1.00b
5.476 (2.127-14.10)
1.00b
0.826 (0.238-2.868)
—
0.087
—
0.028
—
<0.001
—
0.763
GPX1 (rs1050450) Pro/Leu and Leu/Leuh
OR (95% CI)a
0.440 (0.223-0.868)
0.456 (0.188-1.057)
0.553 (0.144-2.120)
2.533 (0.793-8.094)
0.720 (0.239-2.165)
2.194 (0.912-5.287)
0.585 (0.322-1.063)
0.372 (0.115-1.199)
0.018
0.067
0.388
0.117
0.558
0.079
0.079
0.098
aOR: odds ratio adjusted for age, gender, BMI, pack-years, and hypertension; CI: confidence interval; breference group; cC/C: carriers of both referent alleles; dC/A and A/A: carriers of both referent alleles; eAla/Ala: carriers of both referent alleles; fAla/Val and Val/Val: carriers of at least one variant allele; gPro/Pro: carriers of both referent alleles; hPro/Leu and Leu/Leu: carriers of at least one variant allele; iIle/Ile: carriers of both referent alleles; jIle/Val and Val/Val: carriers of at least one variant allele; kAla/Ala: carriers of both referent alleles; lAla/Val and Val/Val: carriers of at least one variant allele.