Metabolomics Analysis of the Development of Sepsis and Potential Biomarkers of Sepsis-Induced Acute Kidney Injury

Figure 3

Histological assessment of kidney injury in PBS- or LPS-treated rats by PAS (periodic acid-Schiff) staining. (a) Control (CT) group. (b) LPS2 group. (c) LPS6 group. PAS staining demonstrated that the structure and morphology of the glomerulus, renal tubules, and renal interstitium were normal in the CT group; the staining of the basement membrane indicated full integrity, and abnormal changes, such as inflammatory cell infiltration and fibrosis, were not detected (a). In the LPS2 (b) and LPS6 groups (c), the lumen of the renal tubules was obviously dilated; the staining of the basement membrane of tubular epithelial cells was discontinuous, and epithelial cells were irregular and of different sizes. The arrangement of renal tubular epithelial cells was more disordered than that in the CT group, and cell shedding was detected.

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