Circular RNAs: Novel Players in the Oxidative Stress-Mediated Pathologies, Biomarkers, and Therapeutic Targets

Figure 3

The role of circRNAs in OxS-moderated AKI. Several factors cause AKI, including diabetes, hypertension, sepsis, and drugs like cisplatin and Losartan. The pathogenesis involves the excessive production of ROS, leading to OxS that triggers inflammation and apoptosis, which finally produces AKI. circRNAs play different roles in this process with different etiologies. All of them work through tethering distinct miRNAs that release mRNA to express proteins with various actions.