Circular RNAs: Novel Players in the Oxidative Stress-Mediated Pathologies, Biomarkers, and Therapeutic Targets

Table 3

The study of circRNAs on OxS in different tissues, systems, or diseases.

Tissue	circRNA	Mediator	Mechanism	Clinical application	Study method	Ref
Ocular: cataract	circZNF292	miR-23b-3p	Alleviates the effect of OxS	Antioxidative therapy	RNA-seq and computational analysis	[85]
Ocular: cataract	circHIPK3	miR-193a/CRYAA	Alleviates the effect of OxS	Antioxidative therapy	RNA-seq and computational analysis. Confirmed by the effect of H2O2in vitro	[86]
Skin	circZNF609	miR-145 -JNK/P38 pathway	Mediates the effect of OxS	Target for antioxidative therapy	Effect of H2O2in vitro	[87]
Liver	circRNA_4099	miR-706	Mediates the H2O2-induced apoptosis	Target for antioxidative therapy	Effect of H2O2 on hepatic cells in vitro	[88]
Dental	Multiple	Multiple	N/A	N/A	Effect of H2O2in vitro	[90]