Review Article
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Figure 2
Different classes of activators of Keap1. Several representative compounds are shown and are divided into Classes I–V (further classified using the criteria established by Suzuki and Yamamoto [55] and based on current studies). 9-OA-NO2: 9-nitro-octadec-9-enoic acid; NaAsO2: sodium meta-arsenite; 4-HNE: 4-hydroxy-nonenal; SNAP: S-nitroso-N-acetylpenicillamine; 15d-PGJ2: 15-deoxy-prostaglandin J2; DMF: dimethylfumarate; CDDO-Im: 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; tBHQ: tert-butylhydroquinone; DEM: diethylmaleate; SFN: sulforaphane; HT-B: hydroxytyrosol butyrate; PPI: protein-protein interaction.