Plasma Small Extracellular Vesicle-Carried miRNA-501-5p Promotes Vascular Smooth Muscle Cell Phenotypic Modulation-Mediated In-Stent Restenosis

Figure 5

Plasma sEV-carried miRNA-501-5p promotes rat carotid artery stenosis. (a) qRT-PCR analysis of pre-miRNA-501-5p and miRNA-501-5p in carotid artery from rats with carotid artery balloon injury (CABI) or sham procedure. Data are normalized to U6. (b) qRT-PCR analysis of pre-miRNA-501-5p and miRNA-501-5p in carotid artery from CABI rats treated with plasma sEV. Data are normalized to U6. (c) Representative hematoxylin-eosin stained images of carotid arteries from CABI rats treated with plasma sEV or antagomir-501-5p. (d) Representative Masson stained images of carotid arteries from CABI rats treated with plasma sEV or antagomir-501-5p. (e and f) Quantitative analysis for media thickness and the ratio of media thickness and lumen diameter. for each group. Values are . and .

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