Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation

Figure 6

The activity of antioxidant enzymes (Cu,Zn-SOD, GSH-Px, GSSG-R, and TrxR) and the level of nonenzymatic antioxidants (GSH, Trx) in the keratinocytes of the skin of control rats, as well as rats’ skin for 4 weeks exposed every 48 hours to UVA (dose increased from 0.5 to 5 J/cm²) or UVB radiation (dose increased from 0.02 to 2 J/cm²) and/or every 12 hours to the action of CBD (2.5% ). The mean values for six rats in each group ± SD are shown as follows: a—differences vs. control group, (a, ; a, ); x—differences vs. UVA-treated group, (x, ; x, ); y—differences vs. UVB-treated group, (y, ; y, ).