The Secretome Deregulations in a Rat Model of Endotoxemic Shock

Table 1

Proteins with a Log₂foldchange (Log₂FC) greater than 1 are highlighted in bold, and proteins with a Log₂FC less than -1 are not in bold.

UniProt accession number	Protein	Gene name	Protein reference described	Log2FC; Median; (min; max)
LPS T50
P06765	Platelet factor 4	Pf4	[12]	3.31 (1.02; 5.20)	5/6
D3ZFH5	Inter-alpha-trypsin inhibitor heavy chain 2	Itih2	—	1.25 (1.08; 2.34)	4/6
P26644	Beta-2-glycoprotein 1	Apoh; B2GPI	[13]	1.45 (1.03; 1.55)
O55004	Ribonuclease 4	RNase 4	—	1.78 (1.70; 2.90)
P00697	Lysozyme C-1	Lyz1	[14]	1.77 (1.70; 2.63)
P23764	Glutathione peroxidase 3	Gpx3	[15]	-2.58 (-1.45; -4.75)	4/6
LPS T90
P17475	Alpha-1-antiproteinase	Serpina1	[16]	3.73 (2.97; 5.65)	5/6
Q99PS8	Histidine-rich glycoprotein	Hrg	[17]	2.39 (1.37; 3.89)
D3ZFH5	Inter-alpha-trypsin inhibitor heavy chain 2	Itih2	—	1.92 (1.58; 3.82)	4/6
Q9QUH3	Apolipoprotein A-V	Apoa5	[18]	1.44 (1.00; 2.24)
P24594	Insulin-like growth factor-binding protein 5	Igfbp5	—	2.14 (1.02; 3.79)
P08650	Complement C5	C5	—	5.27 (3.28; 6.21)
O55004	Ribonuclease 4	Rnase4	—	1.68 (1.28; 2.32)
D3ZTE0	Coagulation factor XII	F12	[19]	1.42 (1.32; 1.73)
P00697	Lysozyme C-1	Lyz1	[14]	2.86 (1.25; 3.81)
Q6IRK9	Carboxypeptidase Q	Cpq	—	1.94 (1.05; 3.34)
P04638	Apolipoprotein A-II	Apoa2	[20]	-1.96 (-1.19; -5.20)	5/6
P55797	Apolipoprotein C-IV	Apoc4	—	-1.88 (-1.37; -2.91)
P20767	Ig lambda-2 chain C region	N/A	—	2.39 (-1.50; -3.30)
Q8R2H5	Phosphatidylinositol-glycan-specific phospholipase D	Gpld1	[21]	-1.48 (-1.02; -2.72)
P14630	Apolipoprotein M	Apom	[22]	-2.94 (-1.46; -4.82)
P23764	Glutathione peroxidase 3	Gpx3	[15]	-2.05 (-1.48; -3.44)
Q68FP1	Gelsolin	Gsn	[23]	-2.05 (-1.67; -4.47)	4/6
P06759	Apolipoprotein C-III	Apoc3	—	-2.60 (-1.08; -3.66)
P55159	Serum paraoxonase/arylesterase 1	Pon1	[24]	-2.15 (-1.17; -2.49)
P02651	Apolipoprotein A-IV	Apoa4	—	-1.54 (-1.04; -2.61)
P35859	Insulin-like growth factor-binding protein complex acid labile subunit	Igfals	—	-2.49 (-2.20; -2.90)
P10960	Prosaposin	Psap	[25]	-2.57 (-1.53; -3.90)

represent the number of rats in which the protein has been found to be deregulated over the 6 rats. Proteins with an asterisk have already been described by other reports in the context of sepsis and septic shock.