Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling

Figure 8

Schematic of proposed mechanism involved in the impairment of the TOPK/PTEN/Akt signaling that has rendered the diabetic hearts to loss responsiveness to sevoflurane postconditioning (SPostC) cardioprotection.