Qiangji Jianli Decoction Alleviates Hydrogen Peroxide-Induced Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics and Biogenesis in L6 Myoblasts

Figure 10

The protective effects of QJJLD on mitochondria. H₂O₂ induced mitochondrial respiratory chain damage, increased the cellular ROS level and consequently reduced ATP content. QJJLD could up-regulate the p-AMPK, PGC-1α, NRF1, and TFAM to promote mitochondrial biogenesis, which resulted in increasing mitochondria number by generating more new mitochondria. The mitochondrial fusion could help the new-generated-functional mitochondria supplement the old-mild-impairment mitochondria through the diffusion between organelles and the sharing of components. The mitochondrial fission would clear the old-severe-impairment mitochondria which resulted in the reduction of ATP. The upregulated mitochondrial fusion and downregulated fission gradually improved the mitochondrial morphology, such as to improve swelling matrix, disarrayed cristae, and disruptive membrane.