Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3
Sirt3 deficiency abolished the antioxidative effects of melatonin following iohexol. (a) Representative western blots. (b) Sirt3 expression. (c) ac-SOD2 K68 expression. (d) Nox4 expression. (e, f) Representative immunohistochemical staining and quantitative analysis of Nox4. (g) Renal MDA content. (h) Renal SOD activity. (i) Renal GSH-Px activity. (j–l) Quantitative analysis of HO-1, Nrf2, and Catalase mRNA expression in the kidney of different groups. (m–o) Quantitative analysis of IL-1β, TNFα, and TGFβ mRNA expression in the kidney of different groups. All experiments were performed at least 3 times. Data are presented as .,,,.
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