Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3
Sirt3 deficiency abolished the antiapoptotic effects of melatonin following iohexol. (a) Representative western blots. (b) Quantitative analysis of the ratio of Bax to Bcl-2. (c) Quantification of the expression of cleaved caspase3. (d) Representative immunohistochemical staining of Bax, Bcl2, and cleaved caspase3. (e–g) Quantification of Bax, Bcl2, and cleaved caspase3. (h) Representative micrographs of apoptotic cells. The apoptotic cells were detected by TUNEL (red), and the nuclei were detected by DAPI (blue). (i) Percentage of TUNEL-positive nuclei. All experiments were performed at least 3 times. Data are expressed as .,,,.
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