D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF-κB Pathway, Mitochondrial Apoptosis, Oxidative Stress, and PCNA

Figure 6

The effects of D-lim (100 mg/kg) on GM-induced kidney histopathological changes observed in the photomicrographs of renal sections stained with H&E. The control group (a, b) shows normal glomeruli and tubules. The D-lim group (c, d) indicates normal kidney architecture similar to the control group. The GM group (e, f) represents massive hyaline casts and tubulorrhexis (necrotic epithelial cells located in the centers of tubules). Additionally, infiltration of leukocytes to the parenchyma (arrows) was observed in the GM group (f). The treated group (g, h) displays amelioration of renal tissue with few casts, a few leukocytes, and desquamated tubules. (a, c, e, g) Low magnification (×100). (b, d, f, h) Higher magnification (×400).