Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration

Figure 1

The severity of LBP showed a correlation with ROS levels in human IVDs. (a) DHE staining suggested a gradual increase in ROS levels along with more severe LBP in patients. (b, c) Linear regression analysis suggested a significant positive correlation between the ROS level in the NP and the VAS score or ODI score. (d) There was a significant negative correlation between the ROS level and the JOA score. (e) When the patients were classified as having mild, moderate, and severe LBP, the ROS levels were significantly gradually increased (<0.001 and <0.01 when compared between different groups. The data are shown as the . , , and for the VAS mild, VAS moderate, and VAS severe groups, respectively. A linear regression model was used for correlation analysis. One-way ANOVA and Tukey’s multiple comparison test were used for multiple group comparisons).

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