Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas

Figure 1

Brusatol (BT) repressed the growth and hormone secretion of pituitary adenomas. (a, b) GH3 and MMQ cells were treated with a range of concentrations of BT for 24 and 48 h. Cell viability was determined by MTS. (c, d) GH3 and MMQ cells were treated with BT for 24 h; formed colonies were photographed and counted using the ImageJ software. (e) Different subtypes of primary pituitary tumor cells were treated with 0.25 μM BT for 24 h; cell viability was determined by MTS. (f) After treating GH3 and MMQ cells with BT (0–500 nM) for 24 h, culture medium supernatants were collected for ELISA to determine the prolactin hormone concentration. (g) After treating GH3 cells with BT (0–500 nM) for 24 h, culture medium supernatants were collected for ELISA to determine the levels of GH hormone. Data are represented as the . ; ; .

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