Sirtuins: Potential Therapeutic Targets for Defense against Oxidative Stress in Spinal Cord Injury

Figure 1

SIRT1 regulates different target genes against oxidative stress. The oxidative stress resistance of SIRT1 is partly attributable to its deacetylation of multiple targets, including PGC-1α, p53, FOXO3a, and NF-κB. Among them, FOXO3a interacts with p53, forming a complex that promotes the binding of p53 and SIRT1, stimulates SIRT1 expression, and inhibits apoptosis and oxidative stress. (ROS: reactive oxygen species; CAT: catalase; MnSOD: manganese superoxide dismutase).