RXRα Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc

Figure 5

RXRα inhibited neurite regeneration after spinal cord injury by downregulating p66shc expression. (a) RXRα agonist significantly inhibited neurite regeneration of the cultured primary spinal cord neurons; this effect can be blocked by p66shc interference in the in vitro cultured primary spinal cord neurons. (b) RXRα antagonist significantly promoted neurite regeneration of the cultured primary spinal cord neurons; this effect was blocked by p66shc overexpression. /group. vs. control, ; vs. control, ; scale bar: 100 μm.

(a)

(b)